An intercomparison has been organized with the purpose to determine the degree of equivalence of several newly developed primary standards for liquid flow rates from 3 mg/h up to 200 mg/h (equivalent with 50 nl/min to 3.3 μl/min). This intercomparison is complementary to EURAMET project 1291/ EURAMET.M.FF.S7 to cover even lower flow rates (project 1291 [...]
Depency on several physical parameters, Reynolds number interpolation, and uncertainty estimation The aim of this report is to determine the influence of various physical parameters and operating conditions on the performance of various types of flow meters. These parameters have been selected that are most relevant for drug delivery applications: viscosity, temperature, back pressure and pulsatile [...]
This best practice guide concerns various aspects related to infusion technology and is developed for clinical users such as nurses and physicians. This guide is put together based on a literature research and on lessons learned from MeDD and focuses on critical drug delivery applications. Here, critical is defined as those applications that require an [...]
MeDD organized a 1-day symposium on infusion technology May 22. This symposium aimed at bringing together researchers, doctors, nurses and clinical physicist in the field of drug delivery. More than 80 people attended from 11 different countries. Below you will find the program and presentations. Session 1 Results MeDD (1) Overview metrology for drug delivery (VSL, [...]
Patients on the Intensive Care Unit almost always require infusion therapy. The continuous and stable infusion of drugs is necessary to stabilize and treat the patient. To predict the infused drug concentration, the UMC has developed a simulation model which is discussed in this technical report.
The UMC Utrecht has developed an in-vitro measurement method to measure concentrations in infusion lines of multi-infusion while simulating several manual disturbances in one or more pumps. This method relies on spectrophotometry and flow meters. The spectrophotometry is used to determine the concentration of added dies whereas the flow meters measure the flow rate of [...]
Medication protocols allow clinicians to administer the correct amount of medication to the patient. Medication protocols may include any procedure necessary to accomplish this goal safely, i.e. to prevent medical/medication errors. In cooperation with the JRP partners, the UMC Utrecht has compiled and disseminated a survey about medication protocols amongst European hospitals. The aim was [...]
DTI and METAS have developed a flow meter performance tester for pulsating flow. The METAS setup covers a flow rate range of 1 ml/min to 1 ml/min with uncertainties ranging from 0.2% to 2.7%, depending on the flow rate and the fit window used. The DTI setup covers a flow rate range of 1 ml/min [...]
At the 2nd International Conference on Microfluidic Handling systems (MFHS 2014), MeDD presented various results. Click here for the proceedings of the volumetric-based primary standard of VSL. Click here for the proceedings of the gravimetric standard of METAS.
M Ahrens, St Klein, B Nestler and C Damiani This work focuses on the design and characterization of a system for measuring and calibration of liquid micro-flows down to 5 nL min−1. The experimental setup relies on a telecentric imaging system mounted on a high-precision, computer controlled linear stage to track a moving liquid meniscus in a [...]